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Istradefylline 40 mg/working day greater peak levels and AUC of CYP3A4 substrates in clinical trials. This influence wasn't observed with istradefylline 20 mg/working day. Take into account dose reduction of delicate CYP3A4 substrates.modafinil will minimize the level or effect of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolis

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